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Title: An efficient mechanochemical synthesis of amides and dipeptides using 2,4,6-trichloro-1,3,5-triazine and PPh<inf>3</inf>
Authors: Chuthamat Duangkamol
Subin Jaita
Sirilak Wangngae
Wong Phakhodee
Mookda Pattarawarapan
Keywords: Chemical Engineering
Issue Date: 1-Jan-2015
Abstract: © The Royal Society of Chemistry. A rapid, facile, and efficient mechanochemical synthesis of amides from carboxylic acids has been developed through an in situ acid activation with 2,4,6-trichloro-1,3,5-triazine and a catalytic amount of PPh<inf>3</inf>. Under room temperature solvent-drop grinding of the reactants in the presence of an inorganic base, a variety of carboxylic acids including aromatic acids, aliphatic acids, and N-protected α-amino acids undergo amidation to afford amides in moderate to excellent yields. The method is also compatible with Fmoc, Cbz, and Boc protecting groups which yields protected optically active dipeptides without detectable racemization.
ISSN: 20462069
Appears in Collections:CMUL: Journal Articles

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