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Title: Catalytic role of PPh<inf>3</inf> and its polymer bound analog in the amidation of carboxylic acids mediated by 2,4,6-trichloro-1,3,5-triazine
Authors: Chuthamat Duangkamol
Subin Jaita
Sirilak Wangngae
Wong Phakhodee
Mookda Pattarawarapan
Keywords: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 27-Jul-2015
Abstract: © 2015 Elsevier Ltd. Abstract The catalytic role of PPh<inf>3</inf> and its polymer bound analog was investigated in the 2,4,6-trichloro-1,3,5-triazine (TCT) mediated amidation of carboxylic acids. In the presence of inorganic bases which were inert toward TCT, carboxylic acids rapidly reacted with amines to afford amides in good to excellent yields. The described method also enabled the synthesis of optically active protected dipeptides without racemization. Formation of triazinylphosphonium chloride during the PPh<inf>3</inf> catalyzed acid activation was confirmed based on <sup>31</sup>P NMR studies.
ISSN: 18733581
Appears in Collections:CMUL: Journal Articles

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