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|Title:||Catalytic role of PPh<inf>3</inf> and its polymer bound analog in the amidation of carboxylic acids mediated by 2,4,6-trichloro-1,3,5-triazine|
|Keywords:||Biochemistry, Genetics and Molecular Biology|
Pharmacology, Toxicology and Pharmaceutics
|Abstract:||© 2015 Elsevier Ltd. Abstract The catalytic role of PPh<inf>3</inf> and its polymer bound analog was investigated in the 2,4,6-trichloro-1,3,5-triazine (TCT) mediated amidation of carboxylic acids. In the presence of inorganic bases which were inert toward TCT, carboxylic acids rapidly reacted with amines to afford amides in good to excellent yields. The described method also enabled the synthesis of optically active protected dipeptides without racemization. Formation of triazinylphosphonium chloride during the PPh<inf>3</inf> catalyzed acid activation was confirmed based on <sup>31</sup>P NMR studies.|
|Appears in Collections:||CMUL: Journal Articles|
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