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Title: Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
Authors: Atchara Jaidee
Thanika Promchai
Kongkiat Trisuwan
Surat Laphookhieo
Roonglawan Rattanajak
Sumalee Kamchonwongpaisan
Stephen G. Pyne
Thunwadee Ritthiwigrom
Keywords: Agricultural and Biological Sciences
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2015
Abstract: One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC50values of 2.46±0.12 and 1.38±0.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity.
ISSN: 15559475
Appears in Collections:CMUL: Journal Articles

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