Please use this identifier to cite or link to this item:
Title: Effect of Swiss-type heterocellular HPFH from XmnI-<sup>G</sup>γ and HBBP1 polymorphisms on HbF, HbE, MCV and MCH levels in Thai HbE carriers
Authors: Sasiwan Kerdpoo
Ektong Limweeraprajak
Thanusak Tatu
Keywords: Medicine
Issue Date: 1-Jan-2014
Abstract: Relationships of Swiss-type heterocellular HPFH as functions of XmnI-Gγ and HBBP1:rs2071348 polymorphisms and HbF, HbE, MCV and MCH in HbE carriers were evaluated in 52 non-anemic and α-thalassemia-free Thai HbE carriers. HbF and HbE levels were measured using cation-exchange HPLC. MCV and MCH were determined using an automated blood counter. The XmnI-Gγ polymorphism was identified by XmnI digestion of amplified products, and the HBBP1:rs2071348 polymorphism by tetra-ARMS-PCR. HbF levels in HbE carriers were higher than those in normal individuals. HbF levels >0.8 % indicated the Swiss-type heterocellular HPFH in these subjects, rendering a prevalence of 40.4 %. The XmnI-Gγ (+) and HBBP1:rs2071348 (C) alleles were modestly positively correlated with elevated HbF, elevated MCH and lowered HbE values. This study thus confirms the influence of the XmnI-Gγ and HBBP1:rs2071348 polymorphisms on HbF production. The present study demonstrates the association of XmnI-Gγ and HBBP1:rs2071348 with HbF, HbE, MCV and MCH in HbE carriers for the first time, and highlights the effect of elevated HbF production on HbE levels. © 2014 The Japanese Society of Hematology.
ISSN: 18653774
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.