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Title: Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia
Authors: Praphan Phanuphak
Sunee Sirivichayakul
Awachana Jiamsakul
Somnuek Sungkanuparph
Nagalingeswaran Kumarasamy
Man Po Lee
Thira Sirisanthana
Pacharee Kantipong
Christopher Lee
Adeeba Kamarulzaman
Mahiran Mustafa
Rossana Ditangco
Tuti Merati
Winai Ratanasuwan
Thida Singtoroj
Rami Kantor
Keywords: Medicine
Issue Date: 1-May-2014
Abstract: BACKGROUND: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens. METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models. RESULTS: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR. CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs. © 2013 by Lippincott Williams and Wilkins.
ISSN: 10779450
Appears in Collections:CMUL: Journal Articles

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