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dc.contributor.authorAnupong Makeudomen_US
dc.contributor.authorSamakorn Kulpawaropasen_US
dc.contributor.authorPattanin Montreekachonen_US
dc.contributor.authorSakornrat Khongkhunthianen_US
dc.contributor.authorThanapat Sastrarujien_US
dc.contributor.authorPeraphan Pothacharoenen_US
dc.contributor.authorPrachya Kongtawelerten_US
dc.contributor.authorSuttichai Krisanaprakornkiten_US
dc.description.abstractAim To measure the levels of hCAP18/LL-37 in gingival crevicular fluid from patients with periodontal diseases compared with healthy controls and to determine the correlation between hCAP18/LL-37 and chondroitin sulphate (CS) levels in patients with periodontitis. Material and Methods Gingival crevicular fluid samples from 51 patients and 25 healthy volunteers were analysed for the hCAP18/LL-37 levels by immunoblotting and were determined for the CS levels by the competitive enzyme-linked immunosorbent assay. Results Tris buffer pH 9.85 was selected to recover hCAP18/LL-37 from Periopaper strips, in which the percentages of recovery were around 70%. The median levels of hCAP18/LL-37 in the aggressive and the chronic periodontitis (CP) groups were significantly greater than those in the gingivitis and the healthy groups (p < 0.05). Significant correlations between the unprocessed 18-kDa fragment and CS levels (r = 0.650; p < 0.001) and between the mature 4.6-kDa fragment and CS levels (r = 0.502; p < 0.001) were observed only in the CP group. Conclusion The significant correlations between the hCAP18/LL-37 and the CS levels were found in CP, but not in aggressive periodontitis. The presence versus absence of such correlations may be clinically applicable to help clinicians distinguish between two distinct types of periodontitis. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.en_US
dc.titlePositive correlations between hCAP18/LL-37 and chondroitin sulphate levels in chronic periodontitisen_US
article.title.sourcetitleJournal of Clinical Periodontologyen_US
article.volume41en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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