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Title: Solvent-free reduction of carboxylic acids to alcohols with NaBH<inf>4</inf> promoted by 2,4,6-trichloro-1,3,5-triazine and PPh<inf>3</inf> in the presence of K<inf>2</inf>CO<inf>3</inf>
Authors: Subin Jaita
Pantitra Kaewkum
Chuthamat Duangkamol
Wong Phakhodee
Mookda Pattarawarapan
Keywords: Chemical Engineering
Issue Date: 1-Jan-2014
Abstract: © the Partner Organisations 2014. A simple, rapid, and eco-friendly method for NaBH4 reduction of carboxylic acids to alcohols under solvent-free conditions was developed using a combination of 2,4,6-trichloro-1,3,5-triazine (TCT) with a catalytic amount of triphenylphosphine as an acid activator. With the 1 : 0.2 : 1.5 : 2 mole ratio of TCT : PPh3 : K2CO3 : NaBH4, carboxylic acids including aromatic acids, aliphatic acids, and N-protected α-amino acids (Fmoc, Z) could readily undergo reduction to give the corresponding alcohols in good to excellent yields within 10 min.
ISSN: 20462069
Appears in Collections:CMUL: Journal Articles

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