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Title: Adherence to antiretroviral therapy and acceptability of planned treatment interruptions in HIV-infected children
Authors: Linda Harrison
Jintanat Ananworanich
Djamel Hamadache
Alexandra Compagnucci
Martina Penazzato
Torsak Bunupuradah
Antonio Mazza
Jose Tomas Ramos
Jacquie Flynn
Osvalda Rampon
Maria Jose Mellado Pena
Daniel Floret
Magdalena Marczynska
Ana Puga
Silvia Forcat
Yoann Riault
Marc Lallemant
Hannah Castro
Diana M. Gibb
Carlo Giaquinto
Keywords: Medicine
Issue Date: 1-Jan-2013
Abstract: There have been no paediatric randomised trials describing the effect of planned treatment interruptions (PTIs) of antiretroviral therapy (ART) on adherence, or evaluating acceptability of such a strategy. In PENTA 11, HIV-infected children were randomised to CD4-guided PTIs (n = 53) or continuous therapy (CT, n = 56). Carers, and children if appropriate, completed questionnaires on adherence to ART and acceptability of PTIs. There was no difference in reported adherence on ART between CT and PTI groups; non-adherence (reporting missed doses over the last 3 days or marking <100 % adherence since the last clinical visit on a visual analogue scale) was 18 % (20/111) and 14 % (12/83) on carer questionnaires in the CT and PTI groups respectively (odds ratios, OR (95 % CI) = 1.04 (0.20, 5.41), χ2(1) = 0.003, p = 0.96). Carers in Europe/USA reported non-adherence more often (31/121, 26 %) than in Thailand (1/73, 1 %; OR (95 % CI) = 54.65 (3.68, 810.55), χ2(1) = 8.45, p = 0.004). The majority of families indicated they were happy to have further PTIs (carer: 23/36, 64 %; children: 8/13, 62 %), however many reported more clinic visits during PTI were a problem (carer: 15/36, 42 %; children: 6/12, 50 %). © 2012 The Author(s).
ISSN: 10907165
Appears in Collections:CMUL: Journal Articles

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