Please use this identifier to cite or link to this item:
Title: Asia-Pacific consensus recommendations for endoscopic and interventional management of hilar cholangiocarcinoma
Authors: Rungsun Rerknimitr
Phonthep Angsuwatcharakon
Thawee Ratanachu-ek
Christopher J.L. Khor
Ryan Ponnudurai
Jong Ho Moon
Dong Wan Seo
Linda Pantongrag-Brown
Apichat Sangchan
Pises Pisespongsa
Thawatchai Akaraviputh
Nageshwar D. Reddy
Amit Maydeo
Takao Itoi
Nonthalee Pausawasdi
Sundeep Punamiya
Siriboon Attasaranya
Benedict Devereaux
Mohan Ramchandani
Khean Lee Goh
Keywords: Medicine
Issue Date: 1-Jan-2013
Abstract: Hilar cholangiocarcinoma (HCCA) is one of the most common types of hepatobiliary cancers reported in the world including Asia-Pacific region. Early HCCA may be completely asymptomatic. When significant hilar obstruction develops, the patient presents with jaundice, pale stools, dark urine, pruritus, abdominal pain, and sometimes fever. Because no single test can establish the definite diagnosis then, a combination of many investigations such as tumor markers, tissue acquisition, computed tomography scan, magnetic resonance imaging/magnetic resonance cholangiopancreatography, endoscopic ultrasonography/intraductal ultrasonography, and advanced cholangioscopy is required. Surgery is the only curative treatment. Unfortunately, the majority of HCCA has a poor prognosis due to their advanced stage on presentation. Although there is no survival advantage, inoperable HCCA managed by palliative drainage may benefit from symptomatic improvement. Currently, there are three techniques of biliary drainage which include endoscopic, percutaneous, and surgical approaches. For nonsurgical approaches, stent is the most preferred device and there are two types of stents i.e. plastic and metal. Type of stent and number of stent for HCCA biliary drainage are subjected to debate because the decision is made under many grounds i.e. volume of liver drainage, life expectancy, expertise of the facility, etc. Recently, radio-frequency ablation and photodynamic therapy are promising techniques that may extend drainage patency. Through a review in the literature and regional data, the Asia-Pacific Working Group for hepatobiliary cancers has developed statements to assist clinicians in diagnosing and managing of HCCA. After voting anonymously using modified Delphi method, all final statements were determined for the level of evidence quality and strength of recommendation. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
ISSN: 14401746
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.