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dc.contributor.authorTheera Tongsongen_US
dc.contributor.authorPimlak Charoenkwanen_US
dc.contributor.authorPannee Sirivatanapaen_US
dc.contributor.authorChanane Wanapiraken_US
dc.contributor.authorWirawit Piyamongkolen_US
dc.contributor.authorSupatra Sirichotiyakulen_US
dc.contributor.authorKasemsri Srisupunditen_US
dc.contributor.authorFuanglada Tongpraserten_US
dc.contributor.authorSuchaya Luewanen_US
dc.contributor.authorThawalwong Ratanasirien_US
dc.contributor.authorRatana Komwilaisaken_US
dc.contributor.authorPiyamas Saksiriwutthoen_US
dc.contributor.authorChutawadi Vuthiwongen_US
dc.contributor.authorPeerapun Punpuckdeekoonen_US
dc.contributor.authorPrisana Panichkulen_US
dc.contributor.authorWibool Rueangchainikhomen_US
dc.contributor.authorJirawat Choowongen_US
dc.contributor.authorNawaporn Orungroteen_US
dc.contributor.authorSravuth Sarapaken_US
dc.contributor.authorEkachai Kovavisarachen_US
dc.contributor.authorPrapon Jaruyawongsen_US
dc.contributor.authorThitinan Tansathiten_US
dc.contributor.authorPodjanee Phadungkiatwattanaen_US
dc.contributor.authorJittima Rujiwetpongstornen_US
dc.contributor.authorOunjai Kor-Anantakulen_US
dc.contributor.authorChitkasaem Suwanrathen_US
dc.contributor.authorTharangrut Hanprasertpongen_US
dc.contributor.authorSavitree Pranpanusen_US
dc.description.abstractObjective: The aim of the research was to determine effectiveness of the model for prenatal control in reducing new cases of severe thalassemia. Methods: Pregnant women at six tertiary centers were recruited to follow the model, consisting of (1) carrier screening using mean corpuscular volume (for alpha-thal-1 and beta-thal) and CMU-E screen (for HbE trait), (2) carrier diagnosis, (3) the couples at risk were counseled and offered prenatal diagnosis, and (4) termination of affected pregnancy. All neonates were evaluated for thalassemia. Results: Of the 12874 recruited pregnancies, 7008 were valid for analysis. Of them, 281 couples were identified to be at risk, Of the 281, 58 affected fetuses were identified and 55 pregnancies were terminated, whereas three did not accept pregnancy termination. All 6727 neonates at no risk were proven to be unaffected. The model had sensitivity and positive predictive value of 100% and 20%, respectively. The model could detect all of affected fetuses. Conclusion: The model could prenatally identify affected fetuses with a detection rate and negative predictive value of 100%. The model was highly effective to prenatally detect affected fetuses with an acceptable false positive rate. © 2013 John Wiley & Sons, Ltd.en_US
dc.titleEffectiveness of the model for prenatal control of severe thalassemiaen_US
article.title.sourcetitlePrenatal Diagnosisen_US
article.volume33en_US Mai Universityen_US Kaen Universityen_US College of Medicineen_US Adulyadej Hospitalen_US Hospitalen_US of Songkla Universityen_US
Appears in Collections:CMUL: Journal Articles

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