Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/52297
Title: Ellagic acid inhibits migration and invasion by prostate cancer cell lines
Authors: Pornsiri Pitchakarn
Teera Chewonarin
Kumiko Ogawa
Shugo Suzuki
Makoto Asamoto
Satoru Takahashi
Tomoyuki Shirai
Pornngarm Limtrakul
Keywords: Biochemistry, Genetics and Molecular Biology
Medicine
Issue Date: 1-Jan-2013
Abstract: Polyphenolic compounds from pomegranate fruit extracts (PFEs) have been reported to possess antiproliferative, pro-apoptotic, anti-inflammatory and anti-invasion effects in prostate and other cancers. However, the mechanisms responsible for the inhibition of cancer invasion remain to be clarified. In the present study, we investigated anti-invasive effects of ellagic acid (EA) in androgen-independent human (PC-3) and rat (PLS10) prostate cancer cell lines in vitro. The results indicated that non-toxic concentrations of EA significantly inhibited the motility and invasion of cells examined in migration and invasion assays. The EA treatment slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 from both cell lines. We further found that EA significantly reduced proteolytic activity of collagenase/gelatinase secreted from the PLS-10 cell line. Collagenase IV activity was also concentration-dependently inhibited by EA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cells through action on protease activity.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880377581&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52297
ISSN: 2476762X
15137368
Appears in Collections:CMUL: Journal Articles

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