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|Title:||Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities|
Marc E. Bouillon
Robert J. Nash
Stephen G. Pyne
|Keywords:||Biochemistry, Genetics and Molecular Biology|
|Abstract:||A concise synthesis of (-)-steviamine is reported along with the synthesis of its analogues 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 μg mL<sup>-1</sup> concentrations) and were found to have in general poor inhibitory activity against most enzymes. The 10-nor analogues however, showed 50-54% inhibition of α-l-rhamnosidase from Penicillium decumbens while one of these, 10-nor-steviamine, showed 51% inhibition of N-acetyl-β-d-glucosaminidase (from Jack bean) at the same concentration (760 μM). © The Royal Society of Chemistry 2013.|
|Appears in Collections:||CMUL: Journal Articles|
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