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dc.contributor.authorPattara Khamrinen_US
dc.contributor.authorAksara Thongprachumen_US
dc.contributor.authorHideaki Kikutaen_US
dc.contributor.authorAtsuko Yamamotoen_US
dc.contributor.authorShuichi Nishimuraen_US
dc.contributor.authorKumiko Sugitaen_US
dc.contributor.authorTsuneyoshi Babaen_US
dc.contributor.authorMasaaki Kobayashien_US
dc.contributor.authorShoko Okitsuen_US
dc.contributor.authorSatoshi Hayakawaen_US
dc.contributor.authorHiroyuki Shimizuen_US
dc.contributor.authorNiwat Maneekarnen_US
dc.contributor.authorHiroshi Ushijimaen_US
dc.description.abstractSaffold virus (SAFV) is a newly discovered human virus in the genus Cardiovirus, family Picornaviridae. The virus was first described from fecal specimens of a child with fever of unknown origin in 2007. A total of 454 fecal specimens were collected from children with diarrhea attended clinics in Japan, 2010-2011, 7 (1.5%) were positive for SAFV. Mixed-infections of SAFV and other enteric viruses (rotavirus, norovirus, and bocavirus) were found in four out of seven cases, while monoinfection by SAFV alone was detected in three cases. In addition to diarrhea, fever and vomiting were observed in three children and mild dehydration in one case. No particular symptoms of cough and rhinorrhea were noted. Analysis of partial VP1 nucleotide sequence of 7 Japanese SAFV strains revealed that 5 SAFV sequences were most closely related with SAFV2 reference strains, but separated into SAFV2-A (3 strains) and SAFV2-B (2 strains). In addition, the other two strains were classified as SAFV3. Our results indicated that SAFVs (SAFV2 and SAFV3) were circulated in children with acute gastroenteritis in Japan during 2010 and 2011 epidemic season. © 2012 Elsevier B.V.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleThree clusters of Saffold viruses circulating in children with diarrhea in Japanen_US
article.title.sourcetitleInfection, Genetics and Evolutionen_US
article.volume13en_US Mai Universityen_US of Tokyoen_US University School of Medicineen_US Institute of Infectious Diseasesen_US
Appears in Collections:CMUL: Journal Articles

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