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|Title:||Extrusion printed polymer structures: A facile and versatile approach to tailored drug delivery platforms|
Simon E. Moulton
Karen S. Santiago
Gordon G. Wallace
|Keywords:||Pharmacology, Toxicology and Pharmaceutics|
|Abstract:||A novel extrusion printing system was used to create drug delivery structures wherein dexamethasone-21-phosphate disodium salt (Dex21P) was encapsulated within a biodegradable polymer (PLGA) and water soluble poly(vinyl alcohol) (PVA) configurations. The ability to control the drug release profile through the spatial distribution of drug within the printed 3-dimensional structures is demonstrated. The fabricated configurations were characterised by optical microscopy and SEM to evaluate surface morphology. The results clearly demonstrate the successful encapsulation of dexamethasone within a laminated PLGA:PVA structure. The resulting drug release profiles from the structures show a two stage release profile with distinctly different release rates and minimal initial burst release observed. Dexamethasone release was monitored over a 4-month period. This approach clearly demonstrates that the extrusion printing technique provides a facile and versatile approach to fabrication of novel drug delivery platforms. © 2011 Elsevier B.V.|
|Appears in Collections:||CMUL: Journal Articles|
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