Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/51979
Title: The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry
Authors: Sorachai Khamsan
Saisunee Liawruangrath
Aphiwat Teerawutkulrag
Stephen Pyne
Mary Garson
Boonsom Liawruangrath
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2012
Abstract: The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on1H,13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863450704&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51979
ISSN: 18469558
13300075
Appears in Collections:CMUL: Journal Articles

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