The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry

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Title:	The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry
Authors:	Sorachai Khamsan Saisunee Liawruangrath Aphiwat Teerawutkulrag Stephen Pyne Mary Garson Boonsom Liawruangrath
Authors:	Sorachai Khamsan Saisunee Liawruangrath Aphiwat Teerawutkulrag Stephen Pyne Mary Garson Boonsom Liawruangrath
Keywords:	Pharmacology, Toxicology and Pharmaceutics
Issue Date:	1-Jun-2012
Abstract:	The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on1H,13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).
URI:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863450704&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51979
ISSN:	18469558 13300075
Appears in Collections:	CMUL: Journal Articles

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