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dc.contributor.authorWisanu Maneeraten_US
dc.contributor.authorWong Phakhodeeen_US
dc.contributor.authorThunwadee Ritthiwigromen_US
dc.contributor.authorSarot Cheenprachaen_US
dc.contributor.authorTrinop Promgoolen_US
dc.contributor.authorKulsiri Yossatheraen_US
dc.contributor.authorSuwanna Deachathaien_US
dc.contributor.authorSurat Laphookhieoen_US
dc.description.abstractThree new carbazole alkaloids, harmandianamines A-C (1-3), together with fifteen known compounds (4-18) were isolated from the twigs of Clausena harmandiana. The structures were elucidated by spectroscopic methods, including UV, IR, NMR, and MS. The antibacterial activity against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466 and methicillin-resistant S. aureus (MRSA) SK1 of some isolated compounds was also evaluated. Compound 6 exhibited significant antibacterial activity against MRSA SK1 with an MIC value of 0.25 μg/mL which higher than that of standard drug, vancomycin (MIC value = 1 μg/mL) whereas compounds 14 and 5 showed strong activity with MIC values of 4 and 8 μg/mL, respectively. Only compound 14 showed strong antibacterial activity against S. aureus TISTR 1466 with an MIC value of 4 μg/mL. © 2012 Elsevier B.V. All rights reserved.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleAntibacterial carbazole alkaloids from Clausena harmandiana twigsen_US
article.volume83en_US Fah Luang Universityen_US Mai Universityen_US of Phayaoen_US
Appears in Collections:CMUL: Journal Articles

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