Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/51974
Title: Caffeic acid phenethyl ester ameliorates cadmium-induced kidney mitochondrial injury
Authors: Anongporn Kobroob
Nipon Chattipakorn
Orawan Wongmekiat
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 25-Oct-2012
Abstract: This study examined whether caffeic acid phenethyl ester (CAPE) can protect kidney mitochondria against cadmium toxicity. Kidney mitochondria isolated from Wistar rat were exposed to cadmium and/or CAPE at various concentrations. Mitochondrial function, ultrastructure and oxidative stress status were determined. Cadmium exposure resulted in mitochondrial swelling, dissipation of membrane potential, overproduction of reactive oxygen species, and impaired ultrastructure. The injury was accompanied by an increase in mitochondrial nitric oxide and malondialdehyde levels as well as a decrease in superoxide dismutase activity and antioxidant thiols. Pretreatment with CAPE ameliorated all the changes caused by cadmium. The results suggest a promising role for CAPE as mitochondria-targeted antioxidant to combat the renal toxicity of cadmium. © 2012 Elsevier Ireland Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866855691&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51974
ISSN: 18727786
00092797
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.