Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/51849
Title: Effects of Kaempferia parviflora Wall. Ex. baker and sildenafil citrate on cGMP level, cardiac function, and intracellular Ca2+ regulation in rat hearts
Authors: Punate Weerateerangkul
Siripong Palee
Kroekkiat Chinda
Siriporn C. Chattipakorn
Nipon Chattipakorn
Keywords: Medicine
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Sep-2012
Abstract: Although Kaempferia parviflora extract (KPE) and its flavonoids have positive effects on the nitric oxide (NO) signaling pathway, its mechanisms on the heart are still unclear. Because our previous studies demonstrated that KPE decreased defibrillation efficacy in swine similar to that of sildenafil citrate, the phosphodiesterase-5 inhibitor, it is possible that KPE may affect the cardiac NO signaling pathway. In the present study, the effects of KPE and sildenafil citrate on cyclic guanosine monophosphate (cGMP) level, modulation of cardiac function, and Ca transients in ventricular myocytes were investigated. In a rat model, cardiac cGMP level, cardiac function, and Ca transients were measured before and after treatment with KPE and sildenafil citrate. KPE significantly increased the cGMP level and decreased cardiac function and Ca transient. These effects were similar to those found in the sildenafil citrate-treated group. Furthermore, the nonspecific NOS inhibitor could abolish the effects of KPE and sildenafil citrate on Ca transient. KPE has positive effect on NO signaling in the heart, resulting in an increased cGMP level, similar to that of sildenafil citrate. This effect was found to influence the physiology of normal heart via the attenuation of cardiac function and the reduction of Ca transient in ventricular myocytes. © 2012 by Lippincott Williams & Wilkins.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866334293&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51849
ISSN: 15334023
01602446
Appears in Collections:CMUL: Journal Articles

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