Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/51462
Title: Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
Authors: Ruangrat Choommongkol
Rattana Jongkol
Samran Prabpai
Palangpon Kongsaeree
Puttinan Meepowpan
Keywords: Chemical Engineering
Chemistry
Issue Date: 15-Mar-2012
Abstract: Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhibited antimalarial activity with IC50values of 3.4-4.7 μg/mL, and importantly displayed non-cytotoxicity to vero cells. © 2012 Elsevier Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860307253&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51462
ISSN: 1362511X
09574166
Appears in Collections:CMUL: Journal Articles

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