Microwave-assisted S NAr reaction of 2,4,6-trichloro-1,3,5- triazine for the rapid synthesis of C 3-symmetrical polycarboxylate ligands

Abstract

The microwave-assisted SNAr reaction of 2,4,6-trichloro-1,3,5- triazine with various unprotected amino acids was developed for the synthesis of C3-symmetrical polycarboxylate ligands which can be used as structural directing units in metal-organic frameworks. The reactions were performed in water using a domestic microwave oven as the heating device. In comparison to the reactions performed under conventional heating, the reactions under microwave irradiation proceeded much more rapidly within 20 min to afford the desired ligands in comparative yields to those obtained by conventional heating. © 2012 Elsevier Ltd. All rights reserved.