Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/51359
Title: Synthesis of stemofoline analogues as acetylcholinesterase inhibitors
Authors: Kwankamol Sastraruji
Thanapat Sastraruji
Alison T. Ung
Renate Griffith
Araya Jatisatienr
Stephen G. Pyne
Keywords: Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 2-Sep-2012
Abstract: Thirty-two new stemofoline analogues were prepared from didehydrostemofoline for studies as AChE inhibitors. C-3 Side-chain modified amino, carbamate, triazole and oxazole stemofoline derivatives were prepared. In general the amine derivatives were found to be stronger inhibitors of AChE than their alcohol analogues that we previously reported. Compounds 5 and 26, with small C-3 side-chain substituents, were two of the most active inhibitors. Preliminary molecular docking studies suggested that these compounds may inhibit AChE by binding horizontally along the passage of the active-site gorge and block access to acetylcholine. © 2012 Elsevier Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863853821&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51359
ISSN: 14645416
00404020
Appears in Collections:CMUL: Journal Articles

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