Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDaniel A. Henken_US
dc.contributor.authorRevital Shahar-Golanen_US
dc.contributor.authorKhuraijam Ranjana Devien_US
dc.contributor.authorKylie J. Boyceen_US
dc.contributor.authorNengyong Zhanen_US
dc.contributor.authorNatalie D. Fedorovaen_US
dc.contributor.authorWilliam C. Niermanen_US
dc.contributor.authorPo Ren Hsuehen_US
dc.contributor.authorKwok Yung Yuenen_US
dc.contributor.authorTran P.M. Sieuen_US
dc.contributor.authorNguyen Van Kinhen_US
dc.contributor.authorHeiman Wertheimen_US
dc.contributor.authorStephen G. Bakeren_US
dc.contributor.authorJeremy N. Dayen_US
dc.contributor.authorNongnuch Vanittanakomen_US
dc.contributor.authorElaine M. Bignellen_US
dc.contributor.authorAlex Andrianopoulosen_US
dc.contributor.authorMatthew C. Fisheren_US
dc.description.abstractMolecular genetic approaches typically detect recombination in microbes regardless of assumed asexuality. However, genetic data have shown the AIDS-associated pathogen Penicillium marneffei to have extensive spatial genetic structure at local and regional scales, and although there has been some genetic evidence that a sexual cycle is possible, this haploid fungus is thought to be genetically, as well as morphologically, asexual in nature because of its highly clonal population structure. Here we use comparative genomics, experimental mixed-genotype infections, and population genetic data to elucidate the role of recombination in natural populations of P. marneffei. Genome wide comparisons reveal that all the genes required for meiosis are present in P. marneffei, mating type genes are arranged in a similar manner to that found in other heterothallic fungi, and there is evidence of a putatively meiosis-specific mutational process. Experiments suggest that recombination between isolates of compatible mating types may occur during mammal infection. Population genetic data from 34 isolates from bamboo rats in India, Thailand and Vietnam, and 273 isolates from humans in China, India, Thailand, and Vietnam show that recombination is most likely to occur across spatially and genetically limited distances in natural populations resulting in highly clonal population structure yet sexually reproducing populations. Predicted distributions of three different spatial genetic clusters within P. marneffei overlap with three different bamboo rat host distributions suggesting that recombination within hosts may act to maintain population barriers within P. marneffei. © 2012 Henk et al.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleClonality Despite Sex: The Evolution of Host-Associated Sexual Neighborhoods in the Pathogenic Fungus Penicillium marneffeien_US
article.title.sourcetitlePLoS Pathogensen_US
article.volume8en_US College Londonen_US Institute of Medical Science Indiaen_US of Melbourneen_US People's Hospitalen_US Craig Venter Instituteen_US Taiwan University Hospitalen_US University of Hong Kongen_US Hospital for Tropical Diseasesen_US University Clinical Research Uniten_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.