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Title: Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles
Authors: Jiraphan Junjhon
Thomas J. Edwards
Utaiwan Utaipat
Valorie D. Bowman
Heather A. Holdaway
Wei Zhang
Poonsook Keelapang
Chunya Puttikhunt
Rushika Perera
Paul R. Chipman
Watchara Kasinrerk
Prida Malasit
Richard J. Kuhn
Nopporn Sittisombut
Keywords: Immunology and Microbiology
Issue Date: 1-Aug-2010
Abstract: During dengue virus replication, an incomplete cleavage of the envelope glycoprotein prM, generates a mixture of mature (prM-less) and prM-containing, immature extracellular particles. In this study, sequential immunoprecipitation and cryoelectron microscopy revealed a third type of extracellular particles, the partially mature particles, as the major prM-containing particles in a dengue serotype 2 virus. Changes in the proportion of viral particles in the pr-M junction mutants exhibiting altered levels of prM cleavage suggest that the partially mature particles may represent an intermediate subpopulation in the virus maturation pathway. These findings are consistent with a model suggesting the progressive mode of prM cleavage. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
ISSN: 10985514
Appears in Collections:CMUL: Journal Articles

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