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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50924| Title: | Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles |
| Authors: | Jiraphan Junjhon Thomas J. Edwards Utaiwan Utaipat Valorie D. Bowman Heather A. Holdaway Wei Zhang Poonsook Keelapang Chunya Puttikhunt Rushika Perera Paul R. Chipman Watchara Kasinrerk Prida Malasit Richard J. Kuhn Nopporn Sittisombut |
| Authors: | Jiraphan Junjhon Thomas J. Edwards Utaiwan Utaipat Valorie D. Bowman Heather A. Holdaway Wei Zhang Poonsook Keelapang Chunya Puttikhunt Rushika Perera Paul R. Chipman Watchara Kasinrerk Prida Malasit Richard J. Kuhn Nopporn Sittisombut |
| Keywords: | Immunology and Microbiology |
| Issue Date: | 1-Aug-2010 |
| Abstract: | During dengue virus replication, an incomplete cleavage of the envelope glycoprotein prM, generates a mixture of mature (prM-less) and prM-containing, immature extracellular particles. In this study, sequential immunoprecipitation and cryoelectron microscopy revealed a third type of extracellular particles, the partially mature particles, as the major prM-containing particles in a dengue serotype 2 virus. Changes in the proportion of viral particles in the pr-M junction mutants exhibiting altered levels of prM cleavage suggest that the partially mature particles may represent an intermediate subpopulation in the virus maturation pathway. These findings are consistent with a model suggesting the progressive mode of prM cleavage. Copyright © 2010, American Society for Microbiology. All Rights Reserved. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954972691&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50924 |
| ISSN: | 10985514 0022538X |
| Appears in Collections: | CMUL: Journal Articles |
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