Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAhmad Haideren_US
dc.contributor.authorLouis J.G. Goorenen_US
dc.contributor.authorPawin Padungtoden_US
dc.contributor.authorFarid Saaden_US
dc.contributor.authorFarid Saaden_US
dc.contributor.authorFarid Saaden_US
dc.description.abstractBackground: Elderly men often show a concurrence of a decline of testosterone with attributes of the metabolic syndrome. This study tested the effects of normalization of testosterone. Materials and methods: A total of 122 hypogonadal men (18-83 years, mean 59.6 ± 8.0 years; n=11<45 years, n = 25<55 years, n = 53<65 years) were included in the study. Their baseline testosterone levels were between 0.14 and 4.51 ng/mL (n>4.90 ng/mL) and were treated with parenteral testosterone undecanoate for 2 years as the sole intervention (administration at 0 and 6 weeks, and thereafter every 12 weeks). Results: Plasma testosterone increased from 3.3 ± 1.9 ng/mL to 4.1 ± 1.5 ng/mL (p<0.01) at 3 months, and then stabilized at 6.8 ± 1.3 ng/mL after the first 6 months. There was a remarkable progressive linear decline in body weight, body mass index, and waist circumference over the entire study period. Plasma cholesterol decreased significantly over the first 12 months, and then stabilized. Plasma glucose, triglyc-erides, low-density lipoprotein cholesterol, and C-reactive protein decreased significantly and high-density lipoprotein cholesterol increased significantly over the 24-month study period in a non-linear manner. There was a significant decrease in aspartate aminotransferase and alanine amino-transferase levels over the first 9 and 12 months, and then values leveled off. Changes in variables were largely corre-lated with changes in testosterone levels. At baseline, 47 out of 122 subjects fulfilled the metabolic syndrome criteria as defined by the National Cholesterol Education Program (2001); after 2 years of testosterone treatment, this number had declined to 11 out of 122 subjects. Conclusion: With testosterone treatment over 2 years, the most significant improvement of the metabolic syndrome was noted over the first 12 months, but over the following 12 months further improvement was also observed. With regard to safety of testosterone administration to mainly elderly men, a number of safety measures were carried out. © 2009, by Walter de Gruyter Berlin New York. All rights reserved.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleBeneficial effects of 2 years of administration of parenteral testosterone undecanoate on the metabolic syndrome and on non-alcoholic liver steatosis and C-reactive proteinen_US
article.title.sourcetitleHormone Molecular Biology and Clinical Investigationen_US
article.volume1en_US Urology Praxisen_US University Medical Centeren_US Mai Universityen_US Pharma AGen_US Medical University School of Medicineen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.