Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/50585
Title: Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
Authors: Vichai Reutrakul
Natthinee Anantachoke
Manat Pohmakotr
Thaworn Jaipetch
Chalobon Yoosook
Jittra Kasisit
Chanita Napaswa
Ampai Panthong
Thawatchai Santisuk
Samran Prabpai
Palangpon Kongsaeree
Patoomratana Tuchinda
Keywords: Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 12-Mar-2010
Abstract: Two new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)- en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O - D-glucopyranoside (5), were isolated from the leaves and twigs of Garcinia hanburyi. Compounds 13 were also isolated from the resin of this plant. The structure of 2 was confirmed by single-crystal X-ray diffraction analysis. All of the lupanes (14) displayed anti-HIV1 activities in the anti-HIV1 reverse transcriptase (ICvalues 16.3116.9g/mL) and syncytium assays (EC5.673.6g/mL, SI 1.73.3). Moreover compounds 14 exhibited anti-inflammatory activity in an ethyl phenylpropiolate (EPP)-induced ear edema model. © Georg Thieme Verlag KG Stuttgart New York.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77749316840&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50585
ISSN: 14390221
00320943
Appears in Collections:CMUL: Journal Articles

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