Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/50569
Title: Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues
Authors: Kwankamol Sastraruji
Thanapat Sastraruji
Stephen G. Pyne
Alison T. Ung
Araya Jatisatienr
Wilford Lie
Keywords: Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 28-May-2010
Abstract: Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1′,2′- didehydrostemofoline (6), which confirmed their structures and absolute configurations. The synthesis of (1′R)-hydroxystemofoline (9) helped establish this compound as a natural product from Stemona aphylla. (1′S)-Hydroxystemofoline (10) and a number of related analogues were also prepared. In a TLC bioautographic assay, 9 was found to be the most active acetylcholinesterase inhibitor, but it was not as active as galanthamine. © 2010 The American Chemical Society and American Society of Pharmacognosy.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952982010&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50569
ISSN: 15206025
01633864
Appears in Collections:CMUL: Journal Articles

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