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dc.contributor.authorHiroyasu Satohen_US
dc.contributor.authorSetsuko Tohnoen_US
dc.contributor.authorTakeshi Minamien_US
dc.contributor.authorTakao Oishien_US
dc.contributor.authorMotoharu Hayashien_US
dc.contributor.authorYoshiyuki Tohnoen_US
dc.description.abstractGender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were -0.178±0.081 (p<0.05) and -0.088±0.022 (p<0.05) in male (n=30), and -0.095±0.026 (p<0.05) and -0.069±0.017 (p<0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca, Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p<0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age- and gender-related SA nodal functions.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleGender-related differences in a process of the age-dependent alterations of the elements in monkey sino-atrial nodeen_US
article.title.sourcetitleKorean Journal of Physiology and Pharmacologyen_US
article.volume14en_US Mai Universityen_US Universityen_US Universityen_US
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