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|Title:||Genotypic linkages of VP4, VP6, VP7, NSP4, NSP5 genes of rotaviruses circulating among children with acute gastroenteritis in Thailand|
Tuan Anh Nguyen
Tuan Anh Nguyen
|Keywords:||Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine|
|Abstract:||Rotavirus is the main cause of acute viral gastroenteritis in infants and young children worldwide. Surveillance of group A rotavirus has been conducted in Chiang Mai, Thailand since 1987 up to 2004 and those studies revealed that group A rotavirus was responsible for about 20-61% of diarrheal diseases in hospitalized cases. In this study, we reported the continuing surveillance of group A rotavirus in 2005 and found that group A rotavirus was detected in 43 out of 147 (29.3%) stool samples. Five different G and P genotype combinations were detected, G1P (27 strains), G2P (12 strains), G9P (2 strains), G3P (1 strain), and G3P (1 strain). In addition, analysis of their genotypic linkages of G (VP7), P (VP4), I (VP6), E (NSP4), and H (NSP5) genotypes demonstrated that the rotaviruses circulating in Chiang Mai, Thailand carried 3 unique linkage patterns. The G1P, G3P, and G9P strains carried their VP6, NSP4, NSP5 genotypes of I1, E1, H1, respectively. The G2P strains were linked with I2, E2, H2 genotypes, while an uncommon G3P genotype carried unique genotypes of I8, E3 and H6. These findings provide the overall picture of genotypic linkage data of rotavirus strains circulating in Chiang Mai, Thailand. © 2010 Elsevier B.V.|
|Appears in Collections:||CMUL: Journal Articles|
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