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Title: Efficacy and safety of enoxaparin during hemodialysis: Results from the HENOX study
Authors: Kriengsak Vareesangthip
Supachai Thitiarchakul
Inseey Kanjanakul
Vasant Sumethkul
Udom Krairittichai
Anutra Chittinandana
Derek Bannachak
Keywords: Medicine
Issue Date: 1-Jan-2011
Abstract: Background: Low molecular weight heparins (LMWHs) have been suggested as an anticoagulant in hemodialysis (HD) since they provide convenient usage, safety and effective outcomes. Objective: Determine clinical efficacy and safety of enoxaparin sodium for the anticoagulation effect during HD in 99 clinically stable end-stage renal disease (ESRD) patients. Material and Method: This prospective open-label study was conducted in seven hemodialysis centers in Thailand. HD prescription during the present study was similar to the previous prescriptions including the type of dialyzer. Enoxaparin sodium 0.7 mg/kg was administered into a pre-dialyzer arterial line at the beginning of the HD session. The anticoagulation effect was monitored by visual inspection of the HD line hourly and inspection of the dialyzer at the end of HD session. Vascular access compression time was monitored at both arterial and venous sites separately at the end of the HD. Results: HD with enoxaparin sodium resulted in no fibrin/clot formation in a hemodialysis line in 97 cases (98%), and no significant clot formation in a dialyzer in 96 cases (97%). The mean vascular compression time was 5.63 ± 1.90 minutes at the arterial site and 5.72 ± 2.61 minutes at the venous site. Neither major adverse events nor major hemorrhages were reported. Prolonged activated partial thromboplastin times (aPTT) at 30 minutes after hemodialysis were reported in two cases. These abnormal aPTT cases returned to normal levels within 24 hours and 72 hours, respectively. Conclusion: The present study suggests that a single-dose regimen of enoxaparin sodium 0.7 mg/kg is an effective, well-tolerated, and convenient alternative to sodium heparin.
ISSN: 01252208
Appears in Collections:CMUL: Journal Articles

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