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Title: The interrelated transmission of HIV-1 and cytomegalovirus during gestation and delivery in the offspring of HIV-infected mothers
Authors: Woottichai Khamduang
Gonzague Jourdain
Wasna Sirirungsi
Prapaisri Layangool
Suparat Kanjanavanit
Pornsuda Krittigamas
Karin Pagdi
Rosalin Somsamai
Surat Sirinontakan
Temsiri Hinjiranandana
Wanna Ardonk
Suchat Hongsiriwon
Sirisak Nanta
Thitiporn Borkird
Marc Lallemant
Kenneth McIntosh
Nicole Ngo-Giang-Huong
Keywords: Medicine
Issue Date: 1-Oct-2011
Abstract: Our objective was to analyze, in formula-fed infants, correlates of HIV mother-to-child transmission, including cytomegalovirus (CMV) infection. HIV-infected infants were matched with HIV uninfected by maternal HIV RNA in a case-control design. Infant CMV infection was determined by CMV IgG at 18 months and timed by earlier CMV IgM or CMV DNA. Correlations were assessed using logistic regression. In utero HIV infection was independently associated with congenital CMV infection (P = 0.01), intrapartum HIV infection with congenital-plus-intrapartum/neonatal CMV infection (P = 0.01), and overall HIV with overall CMV infection (P = 0.001), and prematurity (P = 0.004). Congenital and acquired CMV infections are strong independent correlates of mother-to-child HIV transmission. © 2011 by Lippincott Williams & Wilkins.
ISSN: 10779450
Appears in Collections:CMUL: Journal Articles

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