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dc.contributor.authorT. Anekthananonen_US
dc.contributor.authorW. Manosuthien_US
dc.contributor.authorP. Chetchotisakden_US
dc.contributor.authorS. Kiertiburanakulen_US
dc.contributor.authorK. Supparatpinyoen_US
dc.contributor.authorW. Ratanasuwanen_US
dc.contributor.authorP. G. Pappasen_US
dc.contributor.authorS. G. Filleren_US
dc.contributor.authorH. A. Kopetskieen_US
dc.contributor.authorT. L. Nolenen_US
dc.contributor.authorA. S. Kendricken_US
dc.contributor.authorR. A. Larsenen_US
dc.description.abstractThe aim of this study was to identify baseline prognostic factors for poor clinical outcome of HIV-associated cryptococcal meningitis. We conducted a trial in Thailand and the USA comparing low- and high-dose concomitant use of amphotericin B and fluconazole for HIV-associated cryptococcal meningitis to amphotericin B followed by fluconazole. Subjects who were either alive and cerebrospinal fluid (CSF) culture-positive or dead were considered to have a poor outcome. At day 14, baseline characteristics associated with poor outcome included: low weight, high CSF cryptococcal antigen (CrAg) titre and low CSF white blood cell (WBC) count. At day 70, the associated baseline characteristics included: CSF CrAg titre > 1:1024 and low Karnofsky performance status. Overall, consistent with published findings, low weight, high CSF CrAg titre and low CSF WBC counts at baseline were predictors for poor clinical outcome. In addition, we found that low Karnofsky performance status was predictive of poor outcome. Prompt management with appropriate antifungal therapy for this particular group of patients may improve the outcomes.en_US
dc.titlePredictors of poor clinical outcome of cryptococcal meningitis in HIV-infected patientsen_US
article.title.sourcetitleInternational Journal of STD and AIDSen_US
article.volume22en_US Universityen_US Infectious Diseases Instituteen_US Kaen Universityen_US Mai Universityen_US of Alabamaen_US Geffen School of Medicine at UCLAen_US Federal Systems Division, Inc.en_US Internationalen_US Clinical Research Instituteen_US of Southern Californiaen_US
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