Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/4425
Title: Flow injection chemiluminescence determination of cephalosporins in pharmaceutical preparations using tris (2,2′-bipyridyl) ruthenium (II)-potassium permanganate system
Authors: Thongpoon C.
Liawruangrath B.
Liawruangrath S.
Wheatley R.A.
Townshend A.
Issue Date: 2005
Abstract: A flow injection (FI) method using the tris(2,2′-bipyridyl) ruthenium(II) [Ru(bpy)32+]-potassium permanganate chemiluminescence(CL) was developed for the rapid and sensitive determination of cephalosporins such as cefoxitin, cefazolin, cephalexin, cefadroxil, cefaclor and cefoperazone. The method is based on the CL reaction of cephalosporins and Ru(bpy)32+ with potassium permanganate in the presence of perchloric acid, catalyzed by Mn(II). Under the optimum conditions, the calibration curves are linear over the range 0.10-12.0 μg ml-1 for cefoxitin, 0.10-10.0 μg ml-1 for cefoperazone and 0.10-15.0 μg ml-1 for cefazolin, cephalexin, cefadroxil, and cefaclor, respectively. The limits of detection (3σ) are 0.03 μg ml-1 for cefoxitin and cefadroxil, 0.06 μg ml-1 for cefoperazone and 0.08 μg ml-1 for cefazolin, cephalexin and cefaclor, respectively. The method was successfully applied to the determination of cefoxitin, cefazolin, cephalexin and cefadroxil in pharmaceutical formulations with a sample throughput of 90 h-1. There were no interference effects from some common excipients used in pharmaceutical preparations. © 2005 Elsevier B.V. All rights reserved.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-27144510558&partnerID=40&md5=2a6d85499cb0862a46c9ec5ef1ba6e36
http://cmuir.cmu.ac.th/handle/6653943832/4425
ISSN: 00032670
Appears in Collections:PHARMACY: Journal Articles

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