Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/43372
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dc.contributor.authorChaiwun B.-
dc.contributor.authorNakrungsee S.-
dc.contributor.authorSukhamwang N.-
dc.contributor.authorSrisukho S.-
dc.date.accessioned2017-09-28T06:55:38Z-
dc.date.available2017-09-28T06:55:38Z-
dc.date.issued2010-01-01-
dc.identifier.issn13406868-
dc.identifier.other2-s2.0-73549107209en_US
dc.identifier.other10.1007/s12282-009-0174-0en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73549107209&origin=inward-
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/43372-
dc.description.abstractObjectives: To classify high-nuclear-grade breast cancer (BC) into typical medullary carcinoma (TMC), atypical medullary carcinoma (AMC), and non-medullary carcinoma (NMC), and luminal A, luminal B, and HER2, and to correlate these tumors with other prognostic factors. Materials and methods: A retrospective study reviewing high-nuclear-grade BCs. The patients' age, histologic types, various histologic features, axillary lymph node (ALN) status, and results of immunohistochemical (IHC) study were recorded and analyzed. Results: One-hundred and eighty-one cases of high-nuclear-grade BCs were reviewed and categorized into IDC, NOS (140, 77.3%), TMC (1, 0.6%), AMC (21, 11.6%), and others (19, 10.5%). The median age was younger in AMC than in NMC patients. NMC patients had a higher incidence of LVI and ALN metastasis with involvement of more than four lymph nodes (p = 0.006) whereas AMC patients had a higher mitotic index. Forty-six (35.9%) cases were triple-negative (TN), including 1 (100%), 7 (53.9%) and 38 (33.3%) cases of TMC, AMC, and NMC, respectively. AMC had a significantly lower number of node metastases (p = 0.006) than NMC; whereas TN had higher MI (p = 0.001) than non-TN. The non-TN group was subclassified into luminal A, luminal B, and HER2. Of these, TN and luminal B occurred at younger age (p = 0.01) whereas TN and luminal A had a higher mitotic count. TN had lower incidence of LNM including higher number of LNM. Conclusion: Overall, AMC-TN group showed a basal-like prognostic factor expression. NMC may be separated into TN and non-TN, with possibly different behavior. These sub-groupings should continue to be used. Interestingly, luminal A in our study tended to correlate with poor prognostic factors, thus, luminal A with high nuclear grade may not be representative of the usual luminal group profiles. © 2009 The Japanese Breast Cancer Society.-
dc.titleA study of high-nuclear-grade breast cancer in Thailand: Subclassification and correlation with prognostic factors and immunohistochemical studyen_US
dc.typeJournal-
article.title.sourcetitleBreast Cancer-
article.volume17-
article.stream.affiliationsFaculty of Medicine, Chiang Mai University-
Appears in Collections:CMUL: Journal Articles

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