Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/38504
Title: Risk factors of multidrug-resistant, extensively drug-resistant and pandrug-resistant Acinetobacter baumannii ventilator-associated pneumonia in a Medical Intensive Care Unit of University Hospital in Thailand
Authors: Inchai J.
Liwsrisakun C.
Theerakittikul T.
Chaiwarith R.
Khositsakulchai W.
Pothirat C.
Keywords: Medicine (all)
Pharmacology (medical)
Infectious Diseases
Microbiology (medical)
Issue Date: 2-Nov-2014
Publisher: Springer Japan
Abstract: © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Ventilator-associated pneumonia (VAP) caused by Acinetobacter baumannii remains a significant cause of morbidity and mortality. Increasing antimicrobial resistance influences the selection of antibiotic treatment especially pandrug-resistant A.baumannii. A retrospective cohort study was conducted in the Medical Intensive Care Unit to identify the risk factors of VAP caused by multidrug-resistant A.baumannii (MDR-AB), extensively drug-resistant A.baumannii (XDR-AB) and pandrug-resistant A.baumannii (PDR-AB). All 337 adult patients with confirmed A.baumannii VAP were included. The incidence of MDR-AB, XDR-AB and PDR-AB were 72 (21.4%), 220 (65.3%) and 12 (3.6%), respectively. The risk factor for MDR-AB was prior use of carbapenems (OR 5.20; 95% CI 1.41-19.17). Risk factors for XDR-AB were the prior use of carbapenems (OR, 6.30; 95% CI, 1.80-21.97) and a high Sequential Organ Failure Assessment (SOFA) score (OR 1.35; 95% CI 1.07-1.71). In PDR-AB, the risk factors were the prior use of colistin (OR, 155.95; 95% CI, 8.00-3041.98), carbapenems (OR, 12.84; 95% CI, 1.60-103.20) and a high Simplified Acute Physiology Score (SAPS II) (OR 1.10; 95% CI 1.01-1.22). In conclusion, previous exposure to antibiotics and severity of VAP were risk factors of drug-resistant A. baumannii. Judicious use of carbapenems and colistin is recommended to prevent the antimicrobial-resistant strains of this organism.
URI: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929883396&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38504
ISSN: 1341321X
Appears in Collections:MED: Journal Articles

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