Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/38026
Title: Epistatic QTL pairs associated with meat quality and carcass composition traits in a porcine Duroc × Pietrain population
Authors: Große-Brinkhaus,C.
Jónás,E.A.
Buschbell,H.
Phatsara,C.
Tesfaye,D.
Jüngst,H.G.
Looft,C.
Schellander,K.
Tholen,E.
Keywords: Medicine (all)
Ecology, Evolution, Behavior and Systematics
Genetics
Animal Science and Zoology
Issue Date: 1-Dec-2010
Publisher: BioMed Central
Abstract: Background: Quantitative trait loci (QTL) analyses in pig have revealed numerous individual QTL affecting growth, carcass composition, reproduction and meat quality, indicating a complex genetic architecture. In general, statistical QTL models consider only additive and dominance effects and identification of epistatic effects in livestock is not yet widespread. The aim of this study was to identify and characterize epistatic effects between common and novel QTL regions for carcass composition and meat quality traits in pig. Methods. Five hundred and eighty five F 2 pigs from a Duroc × Pietrain resource population were genotyped using 131 genetic markers (microsatellites and SNP) spread over the 18 pig autosomes. Phenotypic information for 26 carcass composition and meat quality traits was available for all F 2 animals. Linkage analysis was performed in a two-step procedure using a maximum likelihood approach implemented in the QxPak program. Results: A number of interacting QTL was observed for different traits, leading to the identification of a variety of networks among chromosomal regions throughout the porcine genome. We distinguished 17 epistatic QTL pairs for carcass composition and 39 for meat quality traits. These interacting QTL pairs explained up to 8% of the phenotypic variance. Conclusions: Our findings demonstrate the significance of epistasis in pigs. We have revealed evidence for epistatic relationships between different chromosomal regions, confirmed known QTL loci and connected regions reported in other studies. Considering interactions between loci allowed us to identify several novel QTL and trait-specific relationships of loci within and across chromosomes. © 2010 Groe-Brinkhaus et al; licensee BioMed Central Ltd.
URI: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84858132519&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38026
ISSN: 0999193X
Appears in Collections:AGRI: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.