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http://cmuir.cmu.ac.th/jspui/handle/6653943832/7574
2018-08-28T16:45:46ZCharacterization of Thai Silk Fibroin Based Electrospun Nanofibrous Scaffolds for Articular Cartilage Cell Culture
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46038
Title: Characterization of Thai Silk Fibroin Based Electrospun Nanofibrous Scaffolds for Articular Cartilage Cell Culture
Authors: Sathit Banthuek
Abstract: The main objective of this study has been to fabricate the Thai silk fibroin based electrospun nanofibrous scaffolds for articular cartilage cell culture. In this research contribution, electrospinning was used to fabricate silk fibroin (SF) nanofibers from cocoons of indigenous Thai Bombyx mori silkworms (Nangnoi Srisaket-I). The effects of SF concentration (i.e., 20–50% (w/v) in 98% formic acid) and applied voltage (i.e., 15, 20 and 25 kV) on morphology and diameter size of the electrospun SF nanofibrous scaffolds were investigated by Scanning Electron Microscopy (SEM). To confirm the composition structure of silk fibroin, the chemical structure of silk fibroin nanofibers was investigated by Fourier Transform Infra Red Spectroscopy, (FTIR) compare with degummed silk fiberse. The average diameter of the resulting of electrospun SF nanofibrous scaffolds was found to increase with the increase in the solution concentration. Furthermore, the fiber diameter has also been considered as the main factor to influence the mechanical properties of silk fibroin nanofibrous scaffold. These characteristic could provide the utility data of Thai silk fibroin nanofiners for tissue engineering applications. In addition, Electrospinning technique could produce nanofibers in the range of diameter from 100–300 nm. which have nearby diameter size of collagen fibers in articular cartilage extracellular matrix. For Biocompatibily, silk nanofibrous scaffolds showed non-toxicity toward PBMC cell and chondrocyte cell line, sw1353. This contribution provided some characteristic of Thai silk fibroin nanofibers that could be apply for biomaterials and tissue engineering applications.2014-08-01T00:00:00Zพารามิเตอร์ที่เหมาะสมต่อการขึ้นรูปแผ่นเพลทยึดติดกระดูกจากวัสดุประสมของไฮดรอกซีอะปาไทต์และแก้วชีวภาพ
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46007
Title: พารามิเตอร์ที่เหมาะสมต่อการขึ้นรูปแผ่นเพลทยึดติดกระดูกจากวัสดุประสมของไฮดรอกซีอะปาไทต์และแก้วชีวภาพ
Authors: จิดาภา รื่นนารีนารถ
Abstract: Biomaterials have been recently developed and implemented in medical application as an alternative for reactivate or replace fractured parts of bones. Bioactive materials, such as Hydroxyapatite (HA) and bioactive glass (BG) have been increasingly implemented in bone substitution due to their biocompatibility and closely resemble the mineralized phase of human bone structures. Furthermore, the mentioned materials can be synthesized from natural resources (bovine bone and mollusk shell) with calcium-based structures. In this study, the synthesized materials were applied to bone fixation for damaged bone treatment. In addition, the formed composites were compressed by hydraulic pressing machine. The experimental design based on Response Surface Method (RSM) was implemented to evaluate the significant factors of forming condition consists of mixing ratio, pressure and holding time for pressing. The resulting scaffolds were evaluated for ultimate compressive strength and bending strength as the response. The results revealed that all forming conditions and some interaction term have a significant effect on the mechanical property of the composite scaffolds. Consequently, the average compressive strength (154.29 MPa), the average bending strength (17.15 MPa) and density (1.82 g/cm3) was obtained from the scaffold with a 4.53 wt% of BG, 23.41 MPa of pressure and 52.39 second of holding time. Consequently, the information from the mechanical tests was imported into Finite Element Analysis (FEA) in order to evaluate the impacted force behavior of the bone plate when subject to 200 Newton impacted load in axial direction. The result shows that the von Mises stress is 16.2 MPa and the critical location is at the bottom edge of the bone plate.2557-09-01T00:00:00Zการออกแบบโลจิสติกส์ภายในสำหรับการผลิตอาหารกระป๋องโดยใช้เทคนิคการจำลองสถานการณ์
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46004
Title: การออกแบบโลจิสติกส์ภายในสำหรับการผลิตอาหารกระป๋องโดยใช้เทคนิคการจำลองสถานการณ์
Authors: กิตินันธ์ มากปรางค์
Abstract: This research was to study a production line of canned fruits at one factory in Chiang Mai as a case study. The objective of this work was to design internal logistics and determine line balancing of canned fruits production line. Motion study was used to analyze the existing production line. Improvement solutions were proposed based on ECRS concept. Moreover, the optimal configuration can be set including location of each work station, balanced work flow, practical working step and optimal number of workers for each station. After that, conveyor system was designed for this production line. Parameters of conveyor system including type, location, size and speed were calculated and evaluated using simulation technique. Finally, break even point and payback period were calculated for economically evaluation.
The proposed system (ECRS combine with line balancing) was designed to employ with 41 workers reduced from 56 workers comparing with the current production line. The number of workers reduced a effect on 27% labor cost reduction. When conveyor system was proposed total distance can be reduced to 8.6 meters from 16.49 meters (47.85%) and total time was reduced to 45.87 minutes from 67.07 minutes. Brake even point of the conveyor system was to produce 199,543 units per year. And payback period as 2 months.2557-08-01T00:00:00Zการกำหนดเส้นทางแบบสโตแคสติกสำหรับยานพาหนะ เพื่อลดการปล่อยก๊าซคาร์บอนไดออกไซด์
http://cmuir.cmu.ac.th/jspui/handle/6653943832/46003
Title: การกำหนดเส้นทางแบบสโตแคสติกสำหรับยานพาหนะ เพื่อลดการปล่อยก๊าซคาร์บอนไดออกไซด์
Authors: กิ่งกาญจน์ คำสุข
Abstract: This research presents a mathematical model for a Vehicle Routing Problem (VRP) which takes CO2 emission into account by considering weight (vehicle and loading weight) and velocity factors (Minimize CO2 model). The objective is to minimize CO2 emission by determining an appropriate routing and comparing the result with Classical VRP which aims to minimize total distance (Minimize Distance model); then, solve the problem with Tabu Seach (TS) Method.
This study divided into 3 cases classified by vehicle velocity: 15 – 45 km/hr., 45 – 95 km/hr. and 15 – 95 km/hr. Each case was separated into 12 levels by problem size. The number of vehicles was not fixed. Different velocity ranges produced different CO2 emissions. The highest CO2 emission was found at 45 – 95 km/hr., followed by 15 – 95 km/hr., with the lowest at 15 – 45 km/hr. e.g. solution of 5 stations problem, amount of CO2 emission were 13,485 g., 10,871 g. and 7,054 g. respectively.
The solution showed that, although the appropriate route solution from the Minimize CO2 model has longer distance than the appropriate route solution from the Minimize Distance model, CO2 emissions of the Minimize CO2 model was 2.27 % lower, on average. Because of different route sequence affect to the CO2 emission parameter include route constant (αij), velocity (vij) and loading weight (wij).2557-09-01T00:00:00Z